Saccharomyces cerevisiae (R64-1-1)
Description

WD repeat protein required for ubiquitin-mediated protein degradation; ubiquitin binding cofactor that complexes with Cdc48p; required for ribophagy; controls cellular ubiquitin concentration; promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress [Source:SGD;Acc:S000001696]

Gene Synonyms

UFD3, ZZZ4

Location

Chromosome XI: 31,960-34,107 reverse strand.

R64-1-1:BK006944.2

About this gene

This gene has 1 transcript (splice variant), 352 orthologues and is a member of 1 Ensembl protein family.

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  • Name
  • Transcript ID
  • bp
  • Protein
  • Translation ID
  • Biotype
  • UniProt
  • RefSeq
  • Flags
NameTranscript IDbpProteinBiotypeUniProtRefSeqFlags
DOA1YKL213C_mRNA2148715aa
 
Protein coding
P36037 -Ensembl Canonical

Showing the top 9 hits from Europe PubMed Central

PubMed IDTitleAuthorsJournal
38393970Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs.Chuang CN, Liu HC, Woo TT, Chao JL, Chen CY, Hu HT, Hsueh YP, Wang TF.Elife 12 2024
37263996Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores.Smurova K, Damizia M, Irene C, Stancari S, Berto G, Perticari G, Iacovella MG, D'Ambrosio I, Giubettini M, Philippe R, Baggio C, Callegaro E, Casagranda A, Corsini A, Polese VG, Ricci A, Dassi E, De Wulf P.Nat Commun 14 (1) 2023
32668258Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane.Liao PC, Wolken DMA, Serrano E, Srivastava P, Pon LA.Cell Rep 32 (2) 2020
31141470Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress.Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL.Mol Biol Cell 30 (17) 2019
32295767Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae.Eisenstatt JR, Boeckmann L, Au WC, Garcia V, Bursch L, Ocampo J, Costanzo M, Weinreich M, Sclafani RA, Baryshnikova A, Myers CL, Boone C, Clark DJ, Baker R, Basrai MA.G3 (Bethesda) 10 (6) 2020
28450371Adaptive Roles of SSY1 and SIR3 During Cycles of Growth and Starvation in Saccharomyces cerevisiae Populations Enriched for Quiescent or Nonquiescent Cells.Wloch-Salamon DM, Tomala K, Aggeli D, Dunn B.G3 (Bethesda) 7 (6) 2017
29351849The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins.Neal S, Jaeger PA, Duttke SH, Benner C, K Glass C, Ideker T, Hampton RY.Mol Cell 69 (2) 2018
22384346Genome-wide Fitness Profiles Reveal a Requirement for Autophagy During Yeast Fermentation.Piggott N, Cook MA, Tyers M, Measday V.G3 (Bethesda) 1 (5) 2011
12399380A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio.Wilson TE.Genetics 162 (2) 2002