Aspergillus fumigatus Af293 Assembly and Gene Annotation

About the Aspergillus fumigatus genome

Aspergillus fumigatus is a fungus of the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in individuals with an immunodeficiency. A. fumigatus causes more infections worldwide than any other mould. Four percent of all patients dying in tertiary care hospitals in Europe have invasive aspergillosis. The fungus causes allergic deseases in asthmatics and patients suffering from cystic fibrosis. Invasive aspergillosis can occur in individuals with cavities caused by tuberculosis or other cystic lung diseases.

Picture credit: Aspergillus/Aspergillosis Website owned by the Fungal Research Trust

J. Craig Venter Institute and the Sanger Institute sequenced the Aspergillus fumigatus strain Af293 genome at 10.5X coverage using whole genome shotgun (WGS) sequencing. The draft genome was finished, resulting in a final assembly that contains 19 contigs in eight chromosomes.

References

1. CADRE: the Central Aspergillus Data REpository.
   Mabey JE, Anderson MJ, Giles PF, Miller CJ, Attwood TK, Paton NW, Bornberg-Bauer E, Robson GD, Oliver SG, Denning DW. 2004. Nucleic Acids Res.. 32:D401-5.
2. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
   Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, ... , Fraser C, Galagan JE, Asai K, Machida M et al. 2005. Nature. 438:1151-1156.

More information

General information about this species can be found in Wikipedia.