Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA [Source:SGD;Acc:S000003830]

Chromosome X: 568,806-569,399 reverse strand.

This transcript has 1 exon, is annotated with 9 domains and features, is associated with 8 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YJR069C Show transcript tableHide transcript table