Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA [Source:SGD;Acc:S000003830]
Chromosome X: 568,806-569,399 reverse strand.
R64-1-1:BK006943.2
This gene has 1 transcript (splice variant) and 364 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
HAM1 | YJR069C_mRNA | 594 | 197aa | YJR069C | Protein coding | P47119 | - | Ensembl Canonical, |