Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP) [Source:SGD;Acc:S000001583]

Chromosome XI: 253,697-255,460 reverse strand.

This transcript has 1 exon, is annotated with 17 domains and features, is associated with 40 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YKL100C Show transcript tableHide transcript table