Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterograde, retrograde transport between ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; role in ribophagy; cleaves ubiquitin fusions but not polyubiquitin; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000953]

Chromosome V: 469,686-472,424 reverse strand.

This transcript has 1 exon, is annotated with 28 domains and features, is associated with 62 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YER151C Show transcript tableHide transcript table