Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000002364]

Chromosome IV: 92,762-93,745 reverse strand.

This transcript has 1 exon, is annotated with 19 domains and features, is associated with 19 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDL205C Show transcript tableHide transcript table