GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis [Source:SGD;Acc:S000000344]

Chromosome II: 517,350-526,628 reverse strand.

This transcript has 1 exon, is annotated with 31 domains and features, is associated with 222 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YBR140C Show transcript tableHide transcript table