Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000003922]

Chromosome X: 742,848-743,999 reverse strand.

This transcript has 1 exon, is annotated with 7 domains and features, is associated with 198 variant alleles and maps to 66 oligo probes.

This transcript is a product of gene YJR161C Show transcript tableHide transcript table