Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null [Source:SGD;Acc:S000004232]

Chromosome XII: 622,918-623,883 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant) and 233 orthologues.

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