Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy [Source:SGD;Acc:S000000335]
CVT16
Chromosome II: 497,163-499,277 forward strand.
R64-1-1:BK006936.2
This gene has 1 transcript (splice variant) and 17 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
CCZ1 | YBR131W_mRNA | 2115 | 704aa | YBR131W | Protein coding | P38273 | - | Ensembl Canonical, |