Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42 [Source:SGD;Acc:S000000039]

CLS4

Chromosome I: 62,840-65,404 forward strand.

R64-1-1:BK006935.2

This gene has 1 transcript (splice variant) and 255 orthologues.

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